Infectio: Simulation of virus transmission between cells
Infectio is a hybrid stochastic/deterministic simulation software for predictive modeling of how viruses spread between cells in a tissue. The software is open source (GPLv3) and available from GitHub.
When using Infectio please cite this article, in which Infectio is described:
A. Yakimovich, Y. Yakimovich, M. Schmid, J. Mercer, I. F. Sbalzarini, and U. F. Greber. Infectio: a generic framework for computational simulation of virus transmission between cells. mSphere, 1(1):e00078–15, 2016. (PDF,Software Download)
Infectio has previously been used to study the transmission of human Adenovirus type 2 and predict that this happens solely through passive diffusion in the lumen:
A. Yakimovich, H. Gumpert, C. J. Burckhardt, V. A. Lütschg, A. Jurgeit, I. F. Sbalzarini, and U. F. Greber. Cell-free transmission of human adenovirus by passive mass transfer in cell culture simulated in a computer model. J. Virol., 86(18):10123–10137, 2012. (PDF)
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