Modeling and Simulation
This course teaches modeling techniques for spatially resolved biological systems. You will learn to model and simulate biological systems and to develop and implement the corresponding algorithms. After repetition of the basics from mathematics and physics, you will model processes such as diffusion and flow, and simulate them in the computer using your own codes and the numerical framework of particle methods.
dimensionality analysis, causality diagrams, vector fields, particle methods, governing equations for diffusion and flow, hybrid particle-mesh methods for computer simulations, student project: simulation of a biological system.
Lecture: Tuesdays, 4. DS (13:00-14:30), APB-2026 (Andreas-Pfitzmann-Bau) / FIRST LECTURE: APR 5
Exercises: Thursdays, 4. DS (13:00-14:30), MPI-CBG (Pfotenhauerstr. 108) / FIRST TUTORIAL: APR 21
Lecture: Prof. Ivo F. Sbalzarini
Exercises: Dr. Michael Hecht, Pietro Incardona, Anastasia Solomatina
Analysis of the dynamic behavior of biological systems with spatial structure
Formulation of a model of the system behavior
Computer simulation of the model using particle methods
We focus on biological systems. The taught methods and concepts are, however, applicable in a much broader sense.
Lecture language: ENGLISH
Please find below the lecture syllabus, the slides, the self-check questions, and the exercises:
- Lecture 1 - Administration and Introduction
- Lecture 2 - Dimensional Analysis
- Lecture 3 - Modeling Dynamics: Reservoirs and Flows
- Lecture 4 - Recap on Vector Analysis
- Lecture 5 - Conservation Laws and Control Volume Methods
- Lecture 6 - Particle Methods
- Lecture 7 - Diffusion
- Lecture 8 - Reaction-Diffusion
- Lecture 9 - Advection-Diffusion
- Lecture 10 - Flow
- Lecture 11 - PDEs
Full lecture notes will be provided to the students of the course.
The student project will aim at implementing the Quorum Sensing model proposed by J. Müller et al. as described here.